Is it safe to say if I slice the code in Prusaslicer (with added Gcode) and push to that job to Octoprint. The Tool changes and filament swapping should work without intervention? I realize this sounds like a simple question, I just know sometimes things are not as simple as they appear.
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Ok, just in the Octoprint printer setup right?
There is no issue with loading gcode from PrusaSlicer and running it via Octoprint. Just make sure you properly configure Octoprint to expect to see the T0, T1, T2 and T3 extruders... otherwise it will report an error that actually doesn't exist.