I have never had any success. Tried just one colour, 1 filament is loaded into the chameleon. It prints the first layer, but that's about it. I think it's cause maybe the filament switching gradually becomes weaker and can't drive the system.
I'm using a prusa mini btw with prusa slicer 2.3.3 cause the reversedrive doesn't like the temp files in 2.4.1 or 2.4.2.